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KMID : 0370220160600060290
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Yakhak Hoeji
2016 Volume.60 No. 6 p.290 ~ p.296
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Role of K+-Cl--cotranspoter in the Arachidonic Acid-induced Stimulation of Melanin Synthesis in B16 Melanoma Cells
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Lee Yong-Soo
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Abstract
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The effect of arachidonic acid (AA) on melanogenesis was investigated in B16 melanoma cells. AA induced melanogenesis and K+ efflux in a dose-dependent manner, which was significantly inhibited by DIOA, a specific inhibitor of K+-Cl--cotransporter (KCC). These effects of AA were not altered by inhibitors of cyclooxygenase and lipoxygenase. Treatment with ETYA, a non-metabolizable analog of AA induced the same effects as AA did. Taken together, these results suggest that AA itself induced melanogenesis, and that KCC may mediate the effects of AA.
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KEYWORD
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arachidonic acid, melanogenesis, K+-Cl--cotransporter, B16 melanoma cell
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